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A Cellular Adhesion Protein Protects Against Inflammation

is mediated by a group of known as the inflammasome.

In this issue of the Journal of Clinical Investigation, Ziad and colleagues at Addenbrooke’s Hospital in , England, identified a , MFGE8, that blocks inflammasome activity.

Using a mouse model of stroke, Mallat and colleagues determined that expression of MFGE8 inhibited the production of pro-inflammatory products and limited the area of injury after stroke.

These results identify MFGE8 as an important regulator of that could potentially serve as a useful therapeutic target in inflammatory disease.

TITLE: MFGE8 inhibits inflammasome-induced IL-1β production and limits post-ischemic cerebral injury



Journal of Clinical Investigation