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A Gut Feeling About Neural Stem Cells

Proper function of the digestive system requires coordinated contraction of the muscle in the wall of the intestinal tract, regulated by the . Damage or loss of these neurons can result in , such as Hirschsprung’s disease, for which there is a dearth of effective treatments.

In principle, disorders of the enteric nervous system could be treated by cell therapy, but it was previously unknown whether transplanted could migrate to the appropriate location in the gut and then become neurons that could properly innervate the bowel.

In this issue of the Journal of Clinical Investigation, Heather Young and colleagues at , isolated neural stem cells from mice, cultured them to promote the formation of neural precursor cells, and implanted them into the muscle in the colons of recipient mice.

Young and colleagues found that these cells were able to migrate away from the site and develop into neurons that provided stimulation to the portions of the gut the regulate motility. These findings suggest that the of neural stem cells is a promising therapeutic avenue for the treatment of gastrointestinal motility disorders.

TITLE: Transplanted progenitors generate functional in the postnatal colon



Journal of Clinical Investigation