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A high-fat diet induces preeclampsia-like symptoms in pregnant rats

Preeclampsia is a relatively common pregnancy disorder, characterized by primary hypertension and proteinuria.

In patients with , can develop, causing nervous system symptoms and signs. In the clinic, some patients with preeclampsia suffer from even with minimal blood pressure changes. Thus, the pathogenesis of hypertensive encephalopathy cannot fully explain the epilepsy-like attacks in patients. We know that changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks.

A recent study published in (Vol. 8, No. 20, 2013) fed with a high-fat diet for 20 days. Thus, these experienced preeclampsia-like syndromes such as hypertension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus. These findings indicate that increased expression of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in . Therefore, the control of fat intake is significant for the prevention of pregnancy-induced eclampsia.

Article: ” Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?,” by Ge J, Wang J, Xue D, Zhu ZS, Chen ZY, Li XQ, Su DF, Du J. (Neural Regen Res. 2013;8(20):1872-1880.)


Neural Regeneration Research