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A microbial metabolite of linoleic acid ameliorates intestinal inflammation

Inflammatory bowel diseases (IBDs), including and , are hard to completely cure.

Activity of HYA and GPR40
HYA, a microbial metabolite of , ameliorates intestinal barrier damage.
Credit: TANABE ET AL, The , DOI: 10.1074/jbc.M114.610733, FIG.3A


A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway

First Published on December 10, 2014, doi: 10.1074/jbc.M114.610733 January 30, 2015 The Journal of Biological Chemistry, 290, 2902-2918.

Hiroshima University