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A natural sugar delivers DNA aptamer drug inside tumor cells

Drugs comprised of single strands of DNA, called aptamers, can bind to targets inside tumor cells causing cell death. But these DNA drugs cannot readily get inside tumor cells on their own. Effective delivery of DNA aptamers using a natural as a carrier is described in an article in Nucleic Acid Therapeutics, a peer-reviewed journal from , publishers.

Tatyana Zamay and coauthors, , , and (Krasnoyarsk, Russia), and University of Ottawa, Canada, combined the polysaccharide arabinogalactan, obtained from the larch tree, with a DNA drug that binds to and disrupts the activity of vimentin, a structural protein required for cell division. Vimentin is often over-produced by tumor cells compared to normal cells.

In the article “DNA-Aptamer Targeting Vimentin for Tumor Therapy in Vivo” the authors show that an aptamer targeting vimentin inhibits tumor growth more effectively when it is administered as a mixture with arabinogalactan than alone.

“This work demonstrates the advancement of aptamer therapeutic application through increased bioavailability using a nontoxic polysaccharide based therapy,” says Executive Editor Graham C. Parker, PhD.

Source

DNA-Aptamer Targeting Vimentin for Tumor Therapy in Vivo, Authors: ZamayTatyana N., KolovskayaOlga S., GlazyrinYury E., ZamayGalina S., KuznetsovaSvetlana A., SpivakEkaterina A., WehbeMohamed, SavitskayaAnna G., ZubkovaOlga A., KadkinaAnastasia, WangXiaoyan, MuharemagicDarija, DubyninaAnna, SheinaYuliya, SalminaAlla B., BerezovskiMaxim V., and ZamayAnna S.. Nucleic Acid Therapeutics – doi:10.1089/nat.2013.0471.

Mary Ann Liebert, Inc., Publishers