When medication is used to shut off the oxygen supply to tumor cells, the cells adapt their metabolism in the medium term – by switching over to producing energy without oxygen. This observation by biomedical scientists at the University of Basel and University Hospital Basel could be used for treatments that can inhibit tumor growth in the long term, as the researchers report in the latest issue of the journal Cell Reports.
Following anti-angiogenic therapy, tumors develop regions containing no blood vessels (green) and therefore no oxygen (red). The tumor cells are made visible by dyeing the nuclei blue.
Image credit: University of Basel, Department of Biomedicine