Studying aging and its associated diseases has been challenging because existing vertebrate models (e.g., mice) are relatively long lived, while short-lived invertebrate species (e.g., yeast and worms) lack key features present in humans. Stanford University scientists have found a new middle ground with the development of a genome-editing toolkit to study aging in the naturally short-lived African turquoise killifish. The investigators hope these fish will be a valuable new model for understanding, preventing, and treating the diseases of old age. They present their work in the journal Cell.
This is a younger African turquoise killifish.
Harel et al.: “A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebratedoi:10.1016/j.cell.2015.01.038