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A new model organism for aging research: The short-lived African killifish

Studying aging and its associated has been challenging because existing vertebrate models (e.g., mice) are relatively long lived, while short-lived invertebrate species (e.g., yeast and worms) lack key features present in humans. scientists have found a new middle ground with the development of a genome-editing toolkit to study aging in the naturally short-lived African turquoise killifish. The investigators hope these fish will be a valuable new model for understanding, preventing, and treating the of old age. They present their work in the journal Cell.

Young African Turquoise Killifish
This is a younger African turquoise killifish.
Credit:Itamar Harel


Harel et al.: “A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebratedoi:10.1016/j.cell.2015.01.038

Cell Press