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A Trio Of MicroRNAs Contributes To Liver Cancer Progression

are small RNA molecules that regulate the of various genes.

In this issue of the , researchers led by at the identified a trio of microRNAs that reduce the expression of MAT1A. Reduced MAT1A expression is correlated with a worse prognosis in (HCC; liver cancer).

The researchers found that expression of the three microRNAs was induced in human HCC samples. Using a mouse model of HCC, Lu and colleagues demonstrated that reducing expression of these microRNAs resulted in smaller tumors, while increased expression promoted tumor growth and metastasis.

These findings show that the trio of microRNAs are important regulators of HCC growth and could potentially serve as therapeutic targets in cancers associated with decreased MAT1A expression.

Shelly Lu
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA


MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma

Journal of Clinical Investigation Dec. 17, 2012