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Acute Myeloid Leukemia – A Code Of Silence

The development of acute myeloid leukemia () is associated with a variety of . Some of these alterations are epigenetic, wherein the sequence of the genes is unchanged, but chemical modifications to the DNA alter gene expression.

In a study published in the Journal of Clinical Investigation, researchers led by at found that a transcriptional regulator known as C/EBPG was highly expressed in a subset of AML samples that had an epigenetically silenced C/EBPA gene. By blocking the of C/EBPA, Tenen and colleagues found that they could reduce C/EBPG and restore normal myeloid blood cells. This study suggests that targeting the balance of C/EBPG and C/EBPA could represent a new therapeutic approach in the treatment of AML.

TITLE: C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia



Journal of Clinical Investigation