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An experimental Alzheimer’s drug reverses genetic changes thought to spur the disease

Aging takes its toll on the brain, and the cells of the hippocampus–a brain region with circuitry crucial to learning and memory–are particularly vulnerable to changes that can lead to Alzheimer’s disease or cognitive decline. With the hope of counteracting the changes that can lead to these two conditions, researchers at Rockefeller University and their colleagues have begun examining the effects of a drug known to affect this circuitry.

Clean-up
After treatment with riluzole, the brains of old rats showed more of a transporter molecule that removes excess glutamate, (green fluorescence, right) as compared to untreated rats (left).
Credit: Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology at The Rockefeller University/Molecular Psychiatry