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Analogues of a natural product are drug candidates against malaria

is one of the most serious health problems worldwide, registering 200 million clinical cases and more than 600,000 attributable deaths per year, according to information from the in 2013. Given the emerging resistance to the standard treatment most widely used throughout the world, which is based on artemisinin and its analogs, there is a need for new antimalarial compounds.

In this regard, scientists headed by , ICREA researcher at the (), report on a new family of molecules and a new system of action to combat the parasite Plasmodium, causal agent of malaria. Specifically, they describe two derivatives of borrelidin that completely remove the parasite load from mice and confer immunological memory to fight future infections. The latter property is an added value that is not shared by current antimalarial drugs. The results are published in the journal Proceedings of the National Academy of Sciences (PNAS).

Computer simulation of the interaction between the borrelidin analogue BC220 and the tRNA synthetase of Plasmodium
Computer simulation of the interaction between the borrelidin analogue BC220 and the tRNA synthetase of Plasmodium
Credit: IRB Barcelona


Source

Analogs of natural amyniacyl-tRNA synthetase inhibidors clear malaria in vivo, , Noelia Camacho, Anna Tor, Barrie Wilkinson, Steven Moss, Patricia Marín-García, Isabel G. Azcárate, José M. Bautista, Adam C. Mirando, Christopher S. Francklyn, Sònia Varon, Miriam Royo, Alfred Cortés, and Lluís Ribas de Pouplana, PNAS, doi:10.1073/pnas.1405994111, published online 8 December 2014.

Source: Institute for Research in Biomedicine-IRB