Scientists at the University of California, San Diego School of Medicine have found that mutations that cause autism in children are connected to a pathway that regulates brain development. The research, led by Lilia Iakoucheva, PhD, assistant professor in the Department of Psychiatry, is published in the journal Neuron.
Autism mutations may influence brain size through RhoA pathway during fetal brain development.
Credit: UC San Diego School of Medicine
Co-authors include Xinping Yang, David E. Hill and Marc Vidal, Dana-Farber Cancer Institute; Irma Lemmens and Jan Tavernier, Ghent University, Belgium; and Jonathan Sebat, Beyster Center for Genomics of Psychiatric Diseases and UCSD.
This research was funded, in part, by National Institutes of Health (grants R01MH091350, R01HD065288, R21MH104766 and R01MH105524).