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Bacterial Imbalance Contributes To Intestinal Inflammation And Carcinogenesis

Instability in the composition of gut () has been linked to common human intestinal disorders, including and colorectal cancer; however, it is unclear if can instigate disease or if it is a consequence of the underlying disorder.

In this issue of the , researchers led by at the University Lille Nord de France in Lille, France, examined and tumorigenesis in a mouse model of dysbiosis.

Dysbiosis enhanced intestinal inflammation and increased the risk for inflammation-associated colon cancer. Treatment with antibiotics or transplantation of fecal material from normal mice reduced disease risk and instigated long-term, beneficial alterations in intestinal bacteria. Conversely, transplantation of normal mice with dysbiotic fecal material increased intestinal inflammation and enhanced the risk of inflammation-associated colon cancer.

These results demonstrate that gut bacterial communities play an integral role in protecting against intestinal inflammation and associated tumorigenesis.

Source

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer, J Clin Invest. doi:10.1172/JCI62236.

Journal of Clinical Investigation