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Biomolecular force generation based on the principle of a gas spring

The of mitosis has only been understood in fragments so far

Biomolecular Force Generation Based on the Principle of a Gas Spring
The expansion of compressed, weakly bound proteins (green) leads to a force that causes the directional movement of two overlapping microtubules against one another. The upper part of the figure shows a schematic diagram of the movement of two overlapping microtubules (red and orange) in combination with typical fluorescence microscopy images. The lower part of the figure shows a , the macroscopic counterpart of the biomolecular system, where gas is compressed by the impact of an and expands again later as soon as the is reduced.
Credit: Dr.


Original publication: Zdenek Lansky, , Annemarie L├╝decke, , Pieter Rein ten Wolde, Marcel E Janson, Stefan Diez, Diffusible Crosslinkers Generate Directed Forces in Microtubule Networks, DOI:10.1016/j.cell.2015.01.051

Technische Universit├Ąt Dresden