Extracts from the birch tree have served for centuries as a traditional means of helping the damaged skin around wounds to regenerate more quickly. Prof. Dr. Irmgard Merfort from the Institute of Pharmaceutical Sciences of the University of Freiburg and her team have now explained the molecular mechanism behind the wound-healing effect of an extract from the outer white layer of the tree’s bark. The scientists published their findings in the journal Plos One. The team cooperated with several other departments and institutes, such as a research group from the Institute of Molecular Medicine and Cell Research and the Institute of Experimental and Clinical Pharmacology of the University of Freiburg as well as a research group from the Dermatological Clinic of the University of Hamburg.
In the first phase of wound healing, the damaged skin cells release certain substances that lead to a temporary inflammation. They attract phagocytes, which remove foreign bacteria and dead tissue. The Freiburg scientists determined that the birch bark extract, in particular its main ingredient betulin, does in fact temporarily increase the amount of these inflammatory substances. The natural substance activates proteins that extend the half-life of the messenger ribonucleic acid (mRNA). A gene must first be translated into mRNA for the blueprint of a protein to be read by the genome. The substance triples the time in which the mRNA of a particular messenger remains stable. This messenger enables more of the protein in question, in this case the inflammatory substances, to be produced. In addition, the birch bark extract and betulin also stabilize the mRNA of further messengers.
In the second phase of wound healing the skin cells migrate and close the wound. The natural substance aids in this process: The birch cork extract and its components betulin and lupeol activate proteins that are involved in the restructuring of the actin cytoskeleton, which gives the cell its shape with the help of the structural protein actin. In this way, the substances from the birch cause keratinocytes – the most common type of cell in the outermost layer of skin – to migrate more quickly into the wound and close it.
From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract, Authors: Sandra Ebeling, Katrin Naumann, Simone Pollok, Tina Wardecki, Sabine Vidal-y-Sy, Juliana M. Nascimento, Melanie Boerries, Gudula Schmidt, Johanna M. Brandner, Irmgard Merfort, PLOS ONE. DOI: 10.1371/journal.pone.0086147 (2013)