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Blocking apoptotic response could preserve fertility in women receiving cancer treatments

Female cancer patients of reproductive age could preserve their fertility during radiation and chemotherapy through treatments that target the DNA damage response in oocytes (the cells that develop into eggs), an approach that works in animal models.

DNA Damage in Mouse Ovary Treated with Cisplatin
A section of mouse ovary treated with cisplatin (chemotherapy drug) for 24 hours. Red staining labels oocytes, green staining marks DNA damage and blue shows nuclei of all cells.
Credit:The Jackson Laboratory