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Blocking Immune Overreaction

The can run awry in many ways. Some examples of undesirable immune responses include those directed against the host (autoimmunity), transplanted organs (transplant rejection), or a harmless substance (allergies). In each case, the is reacting to the presence of a molecule known as an antigen. Currently, the best treatment options involve broad spectrum suppression of the , which increases susceptibility to infection. A preferable solution would be to specifically turn off the immune cells that respond to non-threatening objects.

In this issue of the , Dr. and colleagues at in La Jolla, California used antigen-decorated nanoparticles to block the development of antibodies to a immune response-inducing antigens in mice. In an accompanying commentary, Edward Clark of the University of Washington discusses how this finding could lead to therapeutic agents capable of precisely controlling our immune system, allowing favorable responses and inhibiting unfavorable responses.

TITLE: Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis

http://www.jci.org/articles/view/69187?key=d3ac5675f0e4224288c1

ACCOMPANYING COMMENTARY TITLE: STALing B cell responses with CD22

http://www.jci.org/articles/view/69670?key=0b5f09cda9a91d9896b6

Source

Journal of Clinical Investigation