3 days popular7 days popular1 month popular3 months popular

Blood Test To Track Huntington’s Disease Progression

Huntington’s disease is a fatal, inherited neurodegenerative disorder caused by a mutation in the gene encoding huntingtin.

Expresion of () protein is correlated with the onset and progression of the disease and new therapies are being developed to reduce the expression of .

In order to evaluate these new therapies, researchers need to be able to quantify the amount of mHTT in a particular patient; however, non-invasive quantification of mHTT isn’t currently possible.

In this issue of the , researchers led by at report that mHTT can be detected in immune cells isolated during a normal blood draw. mHTT levels were significantly correlated with severity, indicating that this test could serve as a non-invasive biomarker for Huntington’s disease.

TITLE: Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression

http://www.jci.org/articles/view/64565?key=7b123462960e2778806d

Source

Journal of Clinical Investigation