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Blood vessel cells improve the conversion of pluripotent stem cells to blood lineages

(HSCs) can differentiate into all of the different types of cells that comprise the blood and immune .

HSC transplantation is the only effective treatment for certain blood disorders; however, sources of HSCs are limited.

(PSCs), such as induced PSCs, can differentiate into multiple types of cell lineages, but they do not readily reconstitute the population of cells in blood.

A new study in the Journal of Clinical Investigation reveals that the presence of , which make up the lining of blood vessels, improves the ability of PSC-derived cells to repopulate blood cell lineages.

Hans-Peter Kiem and colleagues at the Fred Hutchinson Cancer Research Center differentiated PSCs in the presence or absence of endothelial cells. Co-culture with endothelial cells increased the number of progenitor cells and activated hematopoietic specification pathways.

Moreover, in a mouse model, these cells were capable of a long-term engraftment similar to levels achieved with cord blood-derived progenitors. The results of this study support further evaluation of these PSC-derived progenitor cells for transplantation.

TITLE:

Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells

Source

Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells J Clin Invest. doi:10.1172/JCI79328.

Journal of Clinical Investigation