Changes in brain connections visible on MRI could represent an imaging biomarker of Alzheimer’s disease, according to a new study presented at the annual meeting of the Radiological Society of North America (RSNA).
Structural connectomes (top two rows) and corresponding florbetapir PET images (bottom two rows) in four patients with normal cognition (NC) with the lowest whole cortex amyloid burden (left) and the four patients with AD with the highest whole cortex amyloid burden (right) focused on the composite regions used in connectome versus amyloid analysis. Nodes represent the centroids of the FreeSurfer parcellations in the frontal (red), cingulate (green), temporal (light blue), and parietal (dark blue) regions. This is merely a schematic intended to show the concepts and is not intended to show any visually discernible generalizable difference between the patients with NC and those with AD. Structural network metrics provide more sensitive information about the connectome than are apparent through visualization alone.
Other co-authors on the study are P. Murali Doraiswamy, M.D., and Kingshuk R. Choudhury, Ph.D.