Trinity scientists make breakthrough in understanding how parkin, a gene implicated in Parkinson’s disease, controls the repair and replacement of nerve cells.
- The scientists showed that the Parkin protein functions to repair or destroy damaged nerve cells, depending on the degree to which they are damaged
- People living with Parkinson’s disease often have a mutated form of the Parkin gene, which may explain why damaged, dysfunctional nerve cells accumulate
Parkin-expressing cells (red) are undergoing programmed cell death.
Credit: Dr. Emilie Hollville and Professor Seamus Martin, Trinity College Dublin
The work was carried out in Trinity’s School of Genetics and Microbiology. The research team was led by Professor Martin and included Trinity PhD student Richard Carroll and Research Fellow Dr Emilie Hollville. The Trinity research team is internationally recognised for its work on the regulation of cell death.
‘Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1, Cell Press journal, Cell Reports