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Breakthrough in understanding of Parkinson’s disease

Trinity scientists make breakthrough in understanding how parkin, a gene implicated in Parkinson’s disease, controls the repair and replacement of .

  • The scientists showed that the Parkin protein functions to repair or destroy damaged nerve cells, depending on the degree to which they are damaged
  • People living with Parkinson’s disease often have a mutated form of the Parkin gene, which may explain why damaged, dysfunctional nerve cells accumulate
[Parkin-Induced Cell Death (1 of 2)]
Parkin-expressing cells (red) are undergoing programmed cell death.
Credit: Dr. and Professor ,


The work was carried out in Trinity’s School of Genetics and Microbiology. The research team was led by Professor Martin and included Trinity PhD student Richard Carroll and . The Trinity research team is internationally recognised for its work on the regulation of cell death.

‘Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1, Cell Press journal, Cell Reports

Trinity College Dublin