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Cardiac Medication May Help Reduce Stiffness Caused By Nondystrophic Myotonias

Preliminary research finds that for patients with nondystrophic myotonias (), rare diseases that affect the skeletal muscle and cause functionally limiting and pain, use of the anti-arrhythmic medication mexiletine resulted in improvement in patient-reported , according to a preliminary study in the October 3 issue of JAMA.

Data on treatment of NDMs are largely anecdotal, consisting of case series and a single-blind, controlled trials of several medications including mexiletine, according to background information in the article.

, M.D., of the University of Medical Center, , , and colleagues in the Consortium for Clinical Investigation of Neurologic Channelopathies conducted a study to determine the effects of mexiletine for symptoms and signs of (prolonged failure of muscle relaxation after contraction) in patients with NDMs. The randomized study, part of the National Institutes of Health-funded Rare Disease Clinical Research Network, was conducted at seven neuromuscular referral centers in four countries between December 2008 and March 2011 and included 59 patients with NDMs. Patients (33 men, 26 women; average age, 43 years) received either oral 200-mg mexiletine or placebo capsules three times daily for four weeks, followed by the opposite intervention for four weeks, with 1-week washout in between. The main outcome measured for the! study was patient-reported severity score of stiffness recorded on an interactive voice response (IVR) diary (scale of 1 = minimal to 9 = worst ever experienced). Secondary outcomes included IVR-reported changes in pain, weakness, and tiredness; clinical assessment; quantitative measure of handgrip ; and Individualized Neuromuscular Quality of Life summary quality of life score (INQOL-QOL, percentage of maximal detrimental impact).

Data from 57 participants who made telephone calls to the IVR diary in weeks 3 to 4 of period 1 or 2 were included in the analysis. The researchers found that mexiletine was associated with significantly improved stiffness as reported on the IVR diary in both treatment periods. For period 1, the treatment effect was 2.53 for mexiletine vs. 4.21 for placebo; for period 2, 1.60 for mexiletine vs. 5.27 for placebo.

There were significant improvements with mexiletine in most other outcomes in the study, including patient-reported outcomes, quality of life scales, and quantitative measures of myotonia (improved myotonia as measured on clinical examination by overall handgrip times in seconds).

“The most common adverse effect was gastrointestinal (9 mexiletine and 1 placebo). Two participants experienced transient cardiac effects that did not require stopping the study (1 in each group). One serious adverse event was determined to be not study related,” the authors write.

“Our study provides preliminary evidence of the effectiveness of mexiletine for symptoms and signs of myotonia in NDMs,” the researchers write. “The clinical significance of the improvement in stiffness score on the IVR diary is supported by the broad improvement in clinical, quantitative, and electrophysiological measures of myotonia.”

Source

JAMA. 2012;308[13]:1357-1365.

Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

The study was carried out in 59 patients at seven neuromuscular referral centres in four countries, the largest number of which were recruited through the NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust and University College London.

Professor Michael Hanna at the MRC Centre for Neuromuscular Diseases led a UCL team including MRC training fellow Dr Dipa Raja Rayan. Professor Hanna, a senior author on the paper, says: “These disorders can be extremely severe and the effects can stop people from working. Patients who took the repurposed drug, mexilitine, reported that their stiffness improved, they had less pain and they also performed better on handgrip tests. The findings are exciting because this treatment can make the difference between patients being able to work and not, but further research is required.

“It is harder to do clinical trials in rare diseases such as nondystrophic myotonias because individual researchers aren’t able to see the volume of patients required. However, if you are a patient with a rarer disease – something which is harder to study – you should still have access to research and treatment. That’s why we set up this international collaboration to pool our resources and share information. Finding treatments for rarer diseases is an important goal for the NIHR University College London Hospitals Biomedical Research Centre.”

JAMA & University College London