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Cell Therapy For Parkinson’s Disease Generates Dopamine

In Parkinson’s disease, the loss of dopamine-producing cells in the causes well-characterized motor symptoms. Though embryonic stem cells could potentially be used to replace (DA) neurons in Parkinson’s disease patients, such cell therapy options must still overcome technical obstacles before the approach is ready for the clinic. Embryonic stem cell-based regimens carry a risk of introducing inappropriate cells or even cancer-prone cells.

To develop cell purification strategies to minimize these risks, Dr. and colleagues at in New York developed three different mouse lines to fluorescently label dopaminergic neurons at early, mid, and late stages of differentiation. Their data suggest that mouse embryonic stem cells induced to the mid stage of are best suited for transplantation to replace dopaminergic neurons.

Further, their work identified new genes associated with each stage of neuronal differentiation. Their results in the mouse model system help define the differentiation stage and specific attributes of embryonic stem cell-derived, dopamine-generating cells that hold promise for cell therapy applications.

TITLE: Identification of embryonic stem cell-derived midbrain dopaminergic neurons for engraftment


Journal of Clinical Investigation