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Cellular Trojan horse yields potential cancer treatment

A collaborative Brigham and Women’s Hospital (BWH) and Johns Hopkins University (JHU) co-led team has found proof-of-concept evidence for a potential cancer treatment that leverages microparticles and mesenchymal stem cells. The researchers devised an approach to stably internalize chemotherapy loaded microparticles into cells. With the help of a powerful prodrug – developed by collaborators at JHU – that is specifically activated by prostate cells, the researchers effectively targeted and killed prostate cancer tumor cells in proof of concept experiments. The researchers’ results were recently published in Biomaterials.

Cellular Trojan Horse Yields Potential Cancer Treatment
Confocal microscopy image of stem cells loaded with drug containing polymeric microparticles.
Credit: Jeff Karp and Oren Levy, Brigham and Women’s Hospital