Through an extensive international collaboration, scientists at the Center for Selective C-H Functionalization (CCHF), Emory University and the Institute of Transformative Bio-Molecules (ITbM), Nagoya University have synthesized marine alkaloids with anti-cancer and therapeutic properties through a sequential C-H functionalization strategy.
This figure shows the synthesis of marine alkaloid, dictyodendrin, using selective C-H functionalization strategies.
Credit:ITbM, Nagoya University
This article “Concise Syntheses of Dictyodendrins A and F by a Sequential C-H Functionalization Strategy” by Atsushi D. Yamaguchi, Kathryn M. Chepiga, Junichiro Yamaguchi, Kenichiro Itami, and Huw M. L. Davies is published online on January 6, 2015 in the Journal of the American Chemical Society. DOI: 10.1021/ja512059d