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Chemotherapeutic natural products synthesized through selective functionalization

Through an extensive , scientists at the (CCHF), and the (ITbM), have synthesized marine alkaloids with anti-cancer and therapeutic properties through a sequential C-H strategy.

Synthesis of Marine Alkaloid, Dictyodendrin, Using Selective C-H Functionalization Strategies
This figure shows the synthesis of marine alkaloid, dictyodendrin, using selective C-H functionalization strategies.
Credit:ITbM, Nagoya University


This article “Concise Syntheses of Dictyodendrins A and F by a Sequential C-H Functionalization Strategy” by Atsushi D. Yamaguchi, Kathryn M. Chepiga, Junichiro Yamaguchi, Kenichiro Itami, and Huw M. L. Davies is published online on January 6, 2015 in the Journal of the American Chemical Society. DOI: 10.1021/ja512059d

Institute of Transformative Bio-Molecules (ITbM), Nagoya University