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Childhood depression may lead to heart disease by teen years

Children with depression are more likely to be obese, smoke and be inactive, and can show the effects of as early as their teen years, according to a newly published study by University of South Florida Associate Professor of .

The research, by Rottenberg and his colleagues at Washington University and the University of Pittsburgh, suggests that depression may increase the risk of heart problems later in life. The researchers also observed higher rates of heart disease in the parents of adolescents that had been depressed as children. The research is published online in Psychosomatic Medicine and will be included in the medical journal’s February 2014 issue.

“Given that the parents in this sample were relatively young, we were quite surprised to find that the parents of the affected adolescents were reporting a history of heart attacks and other serious events,” Rottenberg explained.

Cardiologists and mental health professionals have long known a link exists between depression and heart disease. Depressed adults are more likely to suffer a heart attack, and if they do have a heart attack, it’s more likely to be fatal.

However it was unclear when the association between clinical depression and cardiac risk develops, or how early in life the association can be detected. These findings suggest improved prevention and treatment of could reduce adult cardiovascular disease.

Heart disease is the leading cause of death for men and women- accounting for one in every four deaths in the United States every year, according to the Centers for Disease Control and Prevention.

During the study, Rottenberg and his colleagues followed up on Hungarian children who had participated in a 2004 study of the genetics of depression. The researchers compared heart disease risk factors – such as smoking, obesity, physical activity level, and parental history – across three categories of adolescents.

The investigators surveyed more than 200 children with a history of clinical depression, as well as about 200 of their siblings who have never suffered from depression. They also gathered information from more than 150 unrelated children of the same age and gender with no history of depression.

Rottenberg plans to conduct additional research in order to understand why depression early in life may put people at increased risk for cardiovascular disease. Further studies planned with the Hungarian group will also examine whether any early warning signs of heart disease are present as these adolescents move into young adulthood.


The Association Between Major Depressive Disorder in Childhood and Risk Factors for Cardiovascular Disease in Adolescence

Additional authors on the PLOS Pathogens paper, “Electron Tomography of HIV-1 Infection in Gut-Associated Lymphoid Tissue,” are Collin Kieffer, a postdoctoral scholar in biology at Caltech; Gregory Olson and Douglas S. Kwon from the Ragon Institute of Massachusetts General Hospital (MGH), MIT, and Harvard; and Maud Deruaz, Vladimir Vrbanac, and Andrew M. Tager from MGH and Harvard Medical School. The work was supported by the Center for the Structural Biology of Cellular Host Elements in Egress, Trafficking and Assembly of HIV (CHEETAH).

California Institute of Technology