Scientists from the Spanish National Cancer Research Centre’s Structural Computational Biology Group, led by Alfonso Valencia, are making the largest ever catalogue of biological chimeras available to the public domain. Specifically, the new database comprises a c ollection of more than 29,000 small RNA molecules–those envolved in making proteins–that originate from different genomic regions. These molecules, the so-called chimeric RNAs, could reveal useful markers for the clinical oncology practice, and even novel drug targets for cancer treatment.
Chromosomal translocations are possibly linked to the origin of cancer.
The study has been funded by the Government of Spain and the European Union.
ChiTaRS 2.1—an improved database of the chimeric transcripts and RNA-seq data with novel sense–antisense chimeric RNA transcripts. Milana Frenkel-Morgenstern, Alessandro Gorohovski, Dunja Vucenovic, Lorena Maestre, Alfonso Valencia. Nucleic Acids Research (2014). doi: 10.1093/nar/gku1199