Thrombocytopenia is a disease characterised by a lower platelet level than normal. Platelets are tiny cells that participate in the coagulation of blood. Patients usually suffer uncontrolled bleeding that gives rise to hematomas and haemorrhages, and even death. Understanding how these cells are produced by the body, then, could be of great use for alleviating the illness, whose incidence increases exponentially in those patients who undergo chemotherapy. Such is the gravity of the symptoms in these patients that they can even lead to the suspension of the treatment.
Two Cdk1-deficient megakaryocytes extend proplatelet elongations to produce platelets.
Credit:Marcos Malumbres, CNIO
The study has been funded by the La Caixa Foundation, the Ramón Areces Foundation, the Ministry of Economy and Competitiveness, the Community of Madrid and the European Union.
Reference article: Functional Reprogramming of Polyploidization in Megakaryocytes. Marianna Trakala, Sara Rodríguez-Acebes, María Maroto, Catherine E. Symonds, David Santamaría, Sagrario Ortega, Mariano Barbacid, Juan Méndez, Marcos Malumbres. Developmental Cell (2015) DOI: 10.1016/j.devcel.2014.12.015