3 days popular7 days popular1 month popular3 months popular

CNIO scientists have discovered a code of signals that regulates genome duplication

Three years ago, the research team directed by Oscar Fernández-Capetillo, head of the Genomic Instability Group at the Spanish National Cancer Research Centre (CNIO), obtained, for the first time, a panoramic view of the proteins that intervene in one of the most important and delicate cellular processes: the copying of genetic material during cellular division. They observed that the parts of the genome where the DNA was copied were also very rich in the modification by some very particular proteins, SUMOylations, and poor in others, ubiquitinations, but they were unable to understand why.

SUMO Protein -- CNIO
SUMO protein with the areas marked with ubiquitin in green.
Credit: CNIO