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CNIO scientists link aggressiveness of chronic lymphocytic leukaemia to genetic variability

The of a tumour could be a predictor for its : the greater the variability in gene expression, the more aggressive the tumour is likely to be. This is the hypothesis that the CNIO Structural Biology and , led by , is testing, after their findings on (CLL), now published in the journal Genome Medicine.

CNIO Grid of Proteins
This is a grid of proteins conferring aggressiveness in CLL (in consistence with the study).
Credit:Simone Ecker. CNIO


Source

The study has been funded by the Ministry of Economy and Competitiveness, the BLUEPRINT Consortium and the Spanish chronic lymphocytic leukaemia project of the International Cancer Genome Consortium (ICGC).

Reference article:

Higher gene expression variability in the more aggressive subtype of chronic lymphocytic leukemia. Simone Ecker, Vera Pancaldi, Daniel Rico, Alfonso Valencia. Genome Medicine (2015). doi: 10.1186/s13073-014-0125-z

Centro Nacional de Investigaciones Oncologicas (CNIO)