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Colorectal Cancer Risk Associated With Inflammatory Bowel Disease

Inflammatory bowel disease is caused by , which leads to damage of the . Patients with inflammatory bowel disease have an elevated risk for developing colorectal cancer because of this chronic .

In an effort to develop strategies to break the cycle of inflammation, Dr. and colleagues at the University of Southern California in Los Angeles examined two mouse models of colorectal cancer. Their work shows that inactivating a key receptor, known as , increases the frequency and severity of colorectal tumors. Though has well-defined roles in promoting tumor growth, the Polk team now finds that can ameliorate the response to chronic inflammation and reduces tumor development by fine-tuning inflammation and the generation of intestinal epithelium.

Their results suggest that promoting epidermal growth factor activity in patients with inflammatory bowel disease could decrease long-term cancer risk by reducing inflammation.

TITLE: Epidermal growth factor receptor inhibits colitis-associated cancer in mice



Journal of Clinical Investigation