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Colorectal Cancer Risk Associated With Inflammatory Bowel Disease

is caused by chronic , which leads to damage of the intestinal epithelium. Patients with inflammatory bowel disease have an elevated risk for developing colorectal cancer because of this chronic .

In an effort to develop strategies to break the cycle of inflammation, Dr. Brent Polk and colleagues at examined two mouse models of colorectal cancer. Their work shows that inactivating a key receptor, known as receptor, increases the frequency and severity of colorectal tumors. Though has well-defined roles in promoting tumor growth, the Polk team now finds that receptor can ameliorate the response to and reduces tumor development by fine-tuning inflammation and the generation of intestinal epithelium.

Their results suggest that promoting epidermal growth factor activity in patients with inflammatory bowel disease could decrease long-term by reducing inflammation.

TITLE: Epidermal growth factor receptor inhibits colitis-associated cancer in mice



Journal of Clinical Investigation