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Colorectal Cancer Risk Associated With Inflammatory Bowel Disease

is caused by chronic , which leads to damage of the intestinal epithelium. Patients with have an elevated risk for developing colorectal because of this .

In an effort to develop strategies to break the cycle of inflammation, Dr. and colleagues at examined two mouse models of colorectal cancer. Their work shows that inactivating a key receptor, known as epidermal growth factor receptor, increases the frequency and severity of colorectal tumors. Though epidermal growth factor has well-defined roles in promoting tumor growth, the Polk team now finds that epidermal growth factor receptor can ameliorate the response to chronic inflammation and reduces tumor development by fine-tuning inflammation and the generation of intestinal epithelium.

Their results suggest that promoting epidermal growth factor activity in patients with inflammatory bowel disease could decrease long-term cancer risk by reducing inflammation.

TITLE: Epidermal growth factor receptor inhibits colitis-associated cancer in mice



Journal of Clinical Investigation