Comparison of fat cells in mice and men hints at how genes and environment conspire to produce diabetes
An analysis of the genomes and epigenomes of lean and obese mice and humans has turned up a wealth of clues about how genes and the environment conspire to trigger diabetes, Johns Hopkins researchers say.
Researchers compared epigenetic “tags” on fat cells of lean and obese mice.
Credit:Oak Ridge National Laboratory
Other authors on the study are Michael L. Multhaup, Marcus M. Seldin, Andrew E. Jaffe, Xia Lei, Varenka Rodriguez, Prosenjit Mondal, Yuanyuan Li and Mehboob Hussain of The Johns Hopkins University; Henriette Kirchner, Juleen R. Zierath and Erik Näslund of the Karolinska Institutet; and Alexander Drong, Cecilia Lindgren and Mark McCarthy of the University of Oxford.