Computer model of nerve cells provides insights into communication problems in diseases of the brain
Study shows the interdependency between the structure and function of neurons
Nerve cells communicate with each other via intricate projections. In brain diseases such as Alzheimer’s and Parkinson’s these extensions atrophy, thereby causing connectivity problems.
Credit: DZNE/Detlef Friedrichs
Dendritic Structural Degeneration is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease. Zuzana Šišková, Daniel Justus, Hiroshi Kaneko, Detlef Friedrichs, Niklas Henneberg, Tatjana Beutel, Julika Pitsch, Susanne Schoch, Albert Becker, Heinz von der Kammer, Stefan Remy. Neuron, 2014, doi: 10.1016/j.neuron.2014.10.024