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Connecting the droplets: a rare disease gene has a key role in chronic hepatitis C infection

Hepatitis C virus (HCV) hijacks the host’s fat metabolism for its own survival, growth, and transport in the human body. A study published on April 28th in PLOS Pathogens identifies a host gene involved in the formation of HCV virus particles and helps explain why humans with a rare mutation in the gene have problems with their fat metabolism.

ABHD5 co-localizes with ADRP to the lipid droplet surface
ABHD5 (green) co-localizes with ADRP (red) to the lipid droplet surface (“donut” shape) in human liver-derived cells.
Image Credit: Gabrielle Vieyres (Twincore, Hannover) (sample preparation & imaging).