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Cooperation between cancer cells makes therapies ineffective, suggests new treatment

between makes current therapies ineffective but also suggests new treatment

Cancer Cells
Cancer cells in vitro form networks like the one pictured here, in which cells not only compete for space and resources, but also cooperate by sharing diffusible . Cells that do not produce , however, can free-ride on the factors produced by their neighbours, forming clusters of non-cooperative cells (dark areas) that can lead to stable intra-tumor heterogeneity. This research shows how the dynamics of production in monolayers of cells can be understood using evolutionary game theory.
Credit:University of East Anglia


Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer‘ doi: 10.1073/pnas.1414653112 is published in the journal PNAS on January 26, 2015. The research was funded by the Natural Environment Research Council (NERC).

University of East Anglia