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Cytoskeletal Dysregulation Underlies Buruli Ulcer Formation

Mycobacterium ulcerans infects the skin and and secretes a lipid toxin, , which causes open , known as Buruli ulcers.

In this issue of the Journal of Clinical Investigation, researchers led by at the in Paris investigated the molecular actions of mycolactone and found that it dysregulates the cellular skeleton (cytoskeleton) through activation of a protein known as N-WASP.

They found that excessive N-WASP activity caused defects in cell adhesion and migration that impaired the integrity of the skin. Demangel and colleagues demonstrated that they could block the degradation process by administration of the N-WASP inhibitor wiskostatin.

These results reveal the molecular pathogenesis of M. ulcerans and suggest that drugs that disrupt mycolactone/N-WASP interaction could be used to treat Buruli ulcers.

TITLE: Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins



Journal of Clinical Investigation