Data shows LBH589 significantly improved progression-free survival in patients with multiple myeloma
Novartis presented results from a pivotal Phase III trial showing a 37% improvement in progression-free survival (PFS) when using the investigational compound LBH589 (panobinostat) in combination with bortezomib and dexamethasone compared to treatment with the same regimen with placebo in patients with relapsed or relapsed and refractory multiple myeloma, meeting the primary endpoint of the study (hazard ratio=0.63 [95% confidence interval (CI): 0.52 to 0.76]; p<0.0001)1. The PANORAMA-1 (PANobinostat ORAl in Multiple MyelomA) trial results were presented in an oral session at the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago.
“Almost all patients with multiple myeloma ultimately relapse and become resistant to treatment, so new therapies are critical for continuing to manage the disease and improve outcomes,” said study investigator Paul Richardson, MD, Clinical Program Leader and Director of Clinical Research, Jerome Lipper Multiple Myeloma Center at Dana-Farber Cancer Institute. “These are the first Phase III results to show meaningful clinical benefit and provide scientific support for adding LBH589 to bortezomib-based treatment for patients with relapsed or relapsed and refractory multiple myeloma and provide a strong rationale for the use of histone deacetylase inhibitors as part of the therapeutic armamentarium in this setting.”
In the LBH589 arm, there was a 4-month prolongation of median PFS (12 months versus 8 months in the placebo arm). The effect of LBH589 was observed across all patient subgroups (for example by age or prior exposure to bortezomib or immunomodulatory therapy)1. The findings also showed that adding LBH589, a pan-deacetylase (pan-DAC) inhibitor, to bortezomib and dexamethasone led to a significant increase in higher quality responses compared to standard-of-care therapy alone, as evidenced by a nearly two-fold increase in complete/near complete response rates (28% versus 16%, respectively; p=0.00006)1.
Side effects were consistent with those previously seen in LBH589 studies. The most common Grade 3/4 adverse events in the LBH589 combination arm were thrombocytopenia (67% versus 31% with placebo), lymphopenia (53% versus 40% with placebo), neutropenia (35% versus 11% with placebo) and diarrhea (26% versus 8% with placebo). Adverse events were generally manageable through supportive care and dose reductions1.
Multiple myeloma, a cancer of white blood cells predominantly affecting the bone marrow, impacts approximately 1 to 5 in every 100,000 people worldwide each year2. With a five-year survival rate of 44%, there is an unmet treatment need for people living with this cancer3. As a pan-DAC inhibitor, LBH589 potentially provides a novel mechanism of action to treat multiple myeloma and works by blocking a key class of cancer cell enzymes, which ultimately leads to cellular stress and death of these cells4.
In May, LBH589 was granted priority review by the US Food and Drug Administration (FDA) and additional global regulatory submissions are underway. FDA priority review status is given to therapies that offer major advances in treatment5.
“LBH589 is a strong example of how our research and development strategy of targeting key pathways in novel ways can benefit patients,” said Alessandro Riva, MD, Global Head, Novartis Oncology Development and Medical Affairs. “PANORAMA-1 data show that adding LBH589 to the standard-of-care treatment for patients with relapsed or relapsed and refractory multiple myeloma offers an innovative and effective treatment option to address an unmet need.”
Additional data from PANORAMA-1 will be presented at upcoming medical congresses this year, including an oral presentation at the 19th Congress of the European Hematology Association (EHA) on June 14 in Milan, Italy.
The PANORAMA-1 (PANobinostat ORAl in Multiple MyelomA) clinical trial is a Phase III randomized, double-blind, placebo-controlled, multicenter global registration trial to evaluate LBH589 in combination with bortezomib and dexamethasone against bortezomib and dexamethasone alone in patients with relapsed or relapsed and refractory multiple myeloma who failed on at least one prior treatment. The study of 768 patients took place in 215 clinical trial sites worldwide. The primary endpoint of the trial was progression-free survival (PFS). Data for overall survival, the key secondary endpoint of the trial, are not yet mature. Other secondary endpoints include overall response rate, duration of response and safety1.
LBH589 is a potent oral pan-inhibitor of class I, II, and IV histone (and non-histone) deacetylase enzymes (HDACs/DACs). It works by blocking a key class of cancer cell enzymes, which ultimately leads to cellular stress and death of these cells4.
Because LBH589 is an investigational compound, the safety and efficacy profile has not yet been established. Access to this investigational compound is available only through carefully controlled and monitored clinical trials. These trials are designed to better understand the potential benefits and risks of the compound. Because of the uncertainty of clinical trials, there is no guarantee that LBH589 will ever be commercially available anywhere in the world.
1. Richardson P, et al. Panorama 1: A Randomized, Double-blind, Phase 3 Study of Panobinostat or Placebo plus Bortezomib and Dexamethasone in Relapsed or Relapsed and Refractory Multiple Myeloma. Abstract #8510. 50th American Society of Clinical Oncology (ASCO) Chicago, IL.
2. Parkin M, et al. Global Cancer Statistics, 2002. CA Cancer J Clin 2005;55:74-108.
3. Pulte D, et al.Recent Improvement in Survival of Patients with Multiple Myeloma: Variation by Ethnicity, Leukemia and Lymphoma. 2013. Available here. ?Accessed November 18, 2013.
4. Novartis Data on File.
5. U.S. Food and Drug Administration. For Consumers. Available here. Accessed May 2014.
6. American Cancer Society. Multiple Myeloma. Available here. Accessed May 2013.
7. The Leukemia and Lymphoma Society. Myeloma. Revised 2013; 1:48. National Cancer Institute. What You Need to Know about Multiple Myeloma. Available at:http://www.cancer.gov/cancertopics/wyntk/myeloma. Accessed May 2013.