3 days popular7 days popular1 month popular3 months popular

Desmoplakin’s tail gets the message

Cells control the adhesion protein by modifying the tail end of the protein, and this process goes awry in some patients with arrhythmogenic cardiomyopathy, according to a study in The Journal of Cell Biology.

Desmoplakin Goes Awry
Desmoplakin (green) normally resides at cell-to-cell junctions (left), but in cells that can’t modify it (right), it associates with (red).
Credit: Albrecht et al., 2015


Source

GSK3- and PRMT-1–dependent modifications of desmoplakin control desmoplakin–cytoskeleton dynamics. Albrecht, L.V., et al. 2015. J. Cell Biol. doi:10.1083/jcb.201406020

Rockefeller University Press