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Discovering a new mechanism for sex control in zebrafish: Reduction of germ cells yields more males

, Hokkaido University and are pleased to announce that their researchers have discovered that the reduction of gonadal will yield more male . The article reporting this finding has been published online in Stem Cell Reports.

These results indicate that a certain number of these specialized gonadal stem cells (primordial or PGCs) is required for ovary formation. Reduced PGC numbers result in more males, as some of the females are forced to change their sex permanently without affecting their fertility, indicating that PGC count plays a regulatory role during sexual differentiation in zebrafish. The findings suggest that a stem cell counting mechanism in the zebrafish gonad is important for determining sexual development, which provides new insight in vertebrate germline biology.

The sex ratio of cultured stocks is an important aspect of aquaculture, as there are distinct differences (e.g. size, colour, maturation, etc.) between the two sexes in several fish species. This discovery may provide potential tools for improved sex control of fishes in farms in the future.

Article: Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation, Keh-Weei Tzung, Rie Goto, Jolly M. Saju, Rajini Sreenivasan, Taiju Saito, Katsutoshi Arai, Etsuro Yamaha, Mohammad Sorowar Hossain, Meredith E.K. Calvert, László Orbán, Stem Cell Reports, DOI: 10.1016/j.stemcr.2014.10.011, published online 26 November 2014.


Source: Temasek Life Sciences Laboratory (Singapore), Hokkaido University (Japan), Ehime University (Japan)