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Discovery of mechanism underlying cisplatin-induced ototoxicity

Studies have shown that calpain participates in gentamicin-, neomycin- and kanamycin-induced inner ear cell apoptosis. Cisplatin has been shown to be an anticancer drug. However, cisplatin can lead to severe , induce cochlear cell apoptosis, and result in hearing decrease or loss, which limits the application of cisplatin in a clinical setting to a certain degree.

A recent study by and colleagues from Jinzhou Central Hospital established a BALB/c mouse model of cisplatin-induced ototoxicity to detect the susceptibility to cisplatin-induced ototoxicity.

Results from this study, published in Neural Regeneration Research (Vol. 8, No. 21, 2013), suggest that calpain 1 and calpain 2 mediate cisplatin-induced ototoxicity in BALB/c mice; during this process, calpain 2 plays a leading role, which can provide evidence for clinical prevention and treatment of deafness caused by cisplatin-induced ototoxicity.

Article: “Calpain mediated cisplatin-induced ototoxicity in mice,” by Liang Chang, Aimei Wang.

Chang L, Wang AM. Calpain mediated cisplatin-induced ototoxicity in mice. Neural Regen Res. 2013;8(21):1995-2002.


Neural Regeneration Research