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Does apolipoprotein E mimetic peptide reduce neuronal apoptosis induced by diffuse brain injury?

Because the majority of patients with diffuse are not suitable candidates for surgery, neuroprotective agents are of great importance.

E exerts a neuroprotective effect against brain injury, but synthetic E cannot cross the blood-brain barrier, thus limiting its application.

It has been reported that apolipoprotein E (138) mimetic peptide can cross the blood-brain barrier in both the normal and injured brain. However, its impact on neurological function following is still unclear.

Prof. and team from the in China conducted a relevant study.

These researchers found that apolipoprotein E-derived therapeutic peptide (0.6mg/kg and 1.2mg/kg) improved synaptic stability and improved learning and memory performance after diffuse brain injury. Furthermore, apolipoprotein E mimetic peptide protected against brain injury by reducing oxidative stress, thereby suppressing the ERK1/2-Bax mitochondrial apoptotic pathway and decreasing neuronal death.

These results have been published in Neural Regeneration Research (Vol. 9, No. 5, 2014).


Neural Regeneration Research