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Drug candidate kills cancer cells through overstimulation

A that overstimulates proteins crucial for tumor growth shows promise as a new strategy to treat a wide range of cancers. The demands of put a strain on , and the approach works by tipping cell stress over the edge. In the August 10 issue of , American researchers show that the drug candidate inhibits tumor growth in a mouse model of and efficiently kills a broad range of human cancer cells.

“No prior drug has been previously developed or proposed that actually stimulates an oncogene to promote therapy,” says co-senior study author David Lonard of Baylor College of Medicine. “Our prototype drug works in multiple types of cancers and encourages us that this could be a more general addition to the cancer drug arsenal.”

Cancer cells
Cancer cells treated with a control (left) and the overstimulating compound MCB-613 (right)
Credit: Lei Wang