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Dysfunctional endosomes are early sign of neurodegeneration

Writing in the April 11 issue of the Journal of Clinical Investigation, researchers at University of California, San Diego School of Medicine say abnormalities in a protein that helps transport and sort materials inside cells are linked to axonal dysfunction and degeneration of neurons in Alzheimer’s disease (AD) and Down syndrome (DS).

This is a false-colored scanning electron micrograph of a human neuron.
Credit: Image courtesy of Thomas Deerinck, NCMIR, UC San Diego.