It is not known what triggered the transmission of Ebola virus from its natural host to humans and the rapid human-to-human spread of the deadly virus throughout Western Africa last year. However, analysis of the blood of patients in Sierra Leone suspected of having Lassa fever, a severe viral illness, between 2011-2014, showed prior exposure to Ebola virus, suggesting that Ebola was present in the area well before the recent outbreak, as reported in Viral Immunology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Viral Immunology website until March 12, 2015.
Matthew Boisen, Corgenix Medical Corporation, Inc. (Broomfield, CO), and a team of authors representing the Viral Hemorrhagic Fever Consortium, found that 22% of patients seen at Kenema Government Hospital in Eastern Sierra Leone for severe viral hemorrhagic fever (VHF) who tested negative for Lassa fever had antibodies in their blood against Ebola virus, evidence of prior exposure to the infectious agent. The authors present their findings in the article entitled “Multiple Circulating Infections Can Mimic the Early Stages of Viral Hemorrhagic Fevers and Possible Human Exposure to Filoviruses in Sierra Leone Prior to the 2014 Outbreak.”
“This is a fascinating observation that will cause us to rethink the dynamics of Ebola virus infections,” says David L. Woodland, PhD, Editor-in Chief of Viral Immunology and Chief Scientific officer for Keystone Symposia on Molecular and Cellular Biology. “A better understanding of the relationship between the virus and its natural and human hosts may help prevent future outbreaks of this dreadful disease.”
Boisen Matthew L., Schieffelin John S., Goba Augustine, Oottamasathien Darin, Jones Abigail B., Shaffer Jeffrey G., Hastie Kathryn M., Hartnett Jessica N., Momoh Mambu, Fullah Mohammed, Gabiki Michael, Safa Sidiki, Zandonatti Michelle, Fusco Marnie, Bornholdt Zach, Abelson Dafna, Gire Stephen K., Andersen Kristian G., Tariyal Ridhi, Stremlau Mathew, Cross Robert W., Geisbert Joan B., Pitts Kelly R., Geisbert Thomas W., Kulakoski Peter, Wilson Russell B., Henderson Lee, Sabeti Pardis C., Grant Donald S., Garry Robert F., Saphire Erica O., Branco Luis M., Khan Sheik Humarr, and the Viral Hemorrhagic Fever Consortium. Viral Immunology. February 2015, 28(1): 19-31. doi:10.1089/vim.2014.0108.