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Effectiveness Of HIV Pre-Exposure Prophylaxis In Men Who Have Sex With Men And Transwomen In Lima, Peru

In this week’s PLOS Medicine, from Imperial College London and an of authors developed a mathematical model representing the epidemic among (MSM) and transwomen in Lima, Peru as a test-case for the effectiveness of HIV pre-exposure (PrEP).

The model was used to investigate the population-level impact, cost, and cost-effectiveness of PrEP under a range of different scenarios.

The authors found that strategic PrEP intervention could be a cost-effective addition to existing for MSM populations. However, despite being cost-effective, a substantial expenditure would be required to generate significant reductions in incidence of HIV.


Funding: This work was principally funded by the Bill & Melinda Gates Foundation. Additional funding: the Medical Research Council UK, The Wellcome Trust, US National Institutes of Health, and The Gladstone Institutes. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests exist.

Citation: Gomez GB, Borquez A, Caceres CF, Segura ER, Grant RM, et al. The Potential Impact of Pre-Exposure Prophylaxis for HIV Prevention among Men Who Have Sex with Men and Transwomen in Lima, Peru: A Mathematical Modelling Study (2012). PLoS Med 9(10): e1001323. doi:10.1371/journal.pmed.1001323