New Salk research shows that high levels of the critical gene Sox10 is tied to aggressive breast cancer. In parts of the adult mammary gland, Sox10 is expressed in cells with higher levels of stem cell activity and not in mature cells that lack detectable stem cell activity. Progesterone receptor (red) indicates non-stem-like mammary cells, which show an inverse correlation with cells expressing Sox10 (blue). A protein called cytokeratin-8 (green) shows the development of the gland.
Credit: Salk Institute
Tags: breast cancer, Molecular Mechanism, mammary gland, mammary cells, mature cells, stem cell activity