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Fetal brain development jeopardized by cannabis use during pregnancy

An increasing number of children suffer from the consequences of maternal drug exposure during pregnancy, and Cannabis is one of the most frequently used substances. This motivated the study, published in the EMBO Journal, conducted in mice and , to decipher the molecular basis of how the major psychoactive component from Cannabis called delta-9-tetrahydrocannabinol or THC affects brain development of the unborn foetus.

The study highlights that consuming Cannabis during pregnancy clearly results in defective development of of the cerebral cortex, the part of the brain that orchestrates higher cognitive functions and drives memory formation. In particular, THC negatively impacts if and how the structural platform and conduit for communication between , the synapses and axons, will develop and function. Researchers also identified Stathmin-2 as a key protein target for THC action, and its loss is characterized as a reason for erroneous nerve growth. It is stressed that Cannabis exposure in experimental models precisely coincided with the fetal period when form connections amongst each other.

According to study leader Professor , who shares his time between and the Medical University Vienna in Austria, these developmental deficits may evoke life-long modifications to the brain function of those affected. Even though not all children who have been exposed to Cannabis will suffer immediate and obvious deficits, warns that relatively subtle damage can significantly increase the risk of delayed neuropsychiatric diseases.

“Even if THC only would cause small changes its effect may well be sufficient to sensitize the brain to later stressors or diseases to provoke neuropsychiatric illnesses in those affected in the future”, says Professor Harkany. “This concerns also the medical use of Cannabis, which should be avoided during pregnancy.”

Source

In addition to researchrs from Sweden and Austria, researchers from the US, Germany, Finland and the UK took part in the study. The work was financed with grants from the Scottish Universities Life Science Alliance, the Swedish Research Council, HjÀrnfonden, the Novo Nordisk Foundation, the Wellcome Trust, and the National Institutes of Health.

‘Miswiring the brain delta-9-tetra-hydro-cannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway’, Giuseppe Tortoriello, Claudia V. Morris, Alan Alpar, Janos Fuzik, Sally L. Shirran, Daniela Calvigioni, Erik Keimpema, Catherine H. Botting, Kirstin Reinecke, Thomas Herdegen, Michael Courtney, Yasmin L. Hurd and Tibor Harkany, EMBO Journal, online 27 January 2014.

Karolinska Institutet