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Finding sheds light on what may kill neurons after stroke

Strokes, seizures, traumatic brain injury and schizophrenia: these conditions can cause persistent, widespread acidity around neurons in the brain. But exactly how that acidity affects brain function isn’t well understood.

N3A Receptor Site
The N3A receptor, as modeled here by the UB researchers, may be silent under normal conditions, but can be reactivated through the unique site (in red) under acidic conditions, such as after a stroke or seizure.
Credit: Gabriela Popescu and Kirstie Cummings