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First Pediatric Study To Look At The Role Of Vitamin D In Critical Illness

Vitamin D is increasingly being recognized as important for good health. Vitamin D is a hormone made in the skin following sun exposure or acquired from diet and supplement intake. Previous has shown that low body levels of vitamin D make people more susceptible to problems such as bone fractures, poor mental health and infections like the common cold. Until recently, there had been little consideration given to the role of vitamin D in more severe diseases, which is why Dr. Dayre ’s recent publication in the esteemed scientific journal Pediatrics is so compelling.

“This is the first study to report on vitamin D levels in a large group of children,” said Dr. McNally, a clinical researcher and intensivist at the Children’s Hospital of Eastern Ontario () and assistant professor in the Department of Pediatrics at the University of Ottawa.

The study, led by Dr. McNally at the , included over 300 children and teenagers at six hospitals in Ottawa, Toronto, Hamilton, Edmonton, Saskatoon and Vancouver. These children were admitted to an Intensive Care Unit (ICU) with severe infections, significant trauma or conditions requiring major surgery, such as .

Their study found that in three of every four critically ill children, blood vitamin D levels were below the target considered safe by many experts and medical societies. Further, those with lower vitamin D levels were noted to be sicker, requiring more life-sustaining therapies (breathing tubes, medications to support heart function) and staying in the ICU for longer periods of time.

“Although these findings are of concern, we are very encouraged because we’ve discovered something that is modifiable,” explained Dr. McNally. “There are simple ways to prevent this problem, and it may be possible to rapidly restore vitamin D levels at the time of severe illness.”

Source

This study was conducted by Dr. Dayre McNally, Dr. Kusum Menon, Dr. Pranesh Chakraborty, Lawrence Fisher, Kathryn Williams, Dr. Osama Al-Dirbashi and Dr. Dermot Doherty. It was funded by the Canadian Institutes of Health Research (CIHR) and the CHEO Research Institute.

Children’s Hospital of Eastern Ontario Research Institute