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Function restored in T cells from lupus patients by targetting lipid metabolism

Patients with the autoimmune disorder lupus erythematosus (SLE) exhibit multiple immune system defects.

In this issue of the , and colleagues at University College London reveal that T cells isolated from have altered membrane-associated lipid profiles and exhibit increased lipid trafficking to the membrane and dysfunctional immune responses.

Furthermore, normalization of in isolated SLE T cells restored membrane lipid levels and immune function.

In an accompanying Commentary, Steven Bensinger and Yoko Kidani of the University of California, Los Angeles discuss how targeting lipid metabolism in SLE patients may help attenuate autoimmunity.

TITLE: Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients


TITLE: Lipids rule: resetting lipid metabolism restores T cell function in systemic lupus erythematosus


Journal of Clinical Investigation